By Maria Chiara Maiuri, Daniela De Stefano
Autophagy mostly serves an adaptive functionality to guard organisms opposed to varied human pathologies, together with melanoma and neurodegeneration. fresh advancements utilizing in vitro, ex vivo and in vivo versions convey the involvement of the autophagy pathway in immunity and irritation. in addition, direct interactions among autophagy proteins and immune signalling molecules have additionally been verified. Defects in autophagy - just like melanoma, neurodegenerative illnesses and getting older - via autophagy gene mutation and/or microbial antagonism, may possibly underlie the pathogenesis of many infectious ailments and inflammatory syndromes. regardless of the expanding expertise of the significance of autophagy in those pathophysiological stipulations, this strategy is still underestimated and is usually neglected. as a result, its function within the initiation, balance, upkeep, and development of those ailments are nonetheless poorly understood. This e-book studies the hot advances in regards to the capabilities of the autophagy pathway and autophagy proteins in immunity and irritation, targeting their function in self-nonself contrast, their implications in innate and adaptive immune responses and their dysregulation within the pathology of definite inflammatory and autoimmune diseases.
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Additional resources for Autophagy Networks in Inflammation
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M001394200 69. Sarkar S (2013) Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers. Biochem Soc Trans 41(5):1103–1130. 1042/BST20130134 70. Sarkar S, Floto RA, Berger Z, Imarisio S, Cordenier A, Pasco M, Cook LJ, Rubinsztein DC (2005) Lithium induces autophagy by inhibiting inositol monophosphatase. J Cell Biol 170(7):1101–1111. 200504035 71. Sarkar S, Korolchuk VI, Renna M, Imarisio S, Fleming A, Williams A, Garcia-Arencibia M, Rose C, Luo S, Underwood BR, Kroemer G, O’Kane CJ, Rubinsztein DC (2011) Complex inhibitory effects of nitric oxide on autophagy.