By Jens Nielsen
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In order to study the MEP pathway, E. coli strains were engineered to allow the study of mutations in otherwise essential genes. For this purpose, in addition to the MEP pathway, E. coli was transformed with the genes encoding mevalonate kinase, phosphomevalonate kinase and diphosphomevalonate decarboxylase. This allowed the study of mutants of the MEP pathway which would have led to the lethality of wild-type cells [119, 120]. Mutants with a defect in the synthesis of IPP from MEP were isolated and the genes responsible for this defect identiﬁed.
Dimster-Denk et al. , showed that Hmg1p was translationally repressed by a non-sterol product of the pathway. C. A. ‡‡‡ [59–61] [35, 57] ‡‡ [49–51] [53, 55] ††† Ref. : Speciﬁc activity expressed as µmol min–1 mg–1 , Km expressed as mM. , ††† : Zooglea ramigera, ‡ : Staphylococcus aureus, ‡‡ : Human,‡‡‡ : Methanococcus jannaschii,. : Streptococcus pneumoniae, .. : Escherichia coli, ... : Bacillus subtilis,∗: Hmg1p, ∗∗ : Hmg2p, a : acetyl-CoA, b : acetoacetyl-CoA, c : ATP, d : IPP, e : DMAPP ERG13 Enzyme Gene Table 4 Properties of the enzymes of the mevalonate pathway of S.
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